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SCFAs produced by probiotic bacteria contribute to immune regulation by inhibiting inflammatory pathways, enhancing the production of anti-inflammatory cytokines, and maintaining intestinal barrier integrity

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Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)